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Maple syrup urine disease punnett square12/2/2023 ![]() In the classical (most severe) form of the disease, a baby born with MSUD develops a severe acidosis (abnormally high levels of acid in the blood) during the first week of life, followed by seizures and coma caused by swelling of the brain tissue, and finally death. In all three cases, the three BCAAs and their byproducts, which are called ketoacids, build up in the urine, blood, and other body tissues. The patient may lack the enzyme complex entirely, it may be inactivated, or it may be only partially active. ![]() ![]() A person diagnosed with MSUD lacks the enzyme complex that is needed to break down the three BCAA s. MSUD is an inborn metabolic disorder ( IMD ), which means that it is a heritable disease characterized by the body’s inability to process one or more specific substances essential to health. Description Maple syrup urine disease (MSUD) The MSUD diet of the early 2000s as modified for different age groups is described in further detail below. Dietary therapy of MSUD thus consists of a combination of protein substitutes containing amino acids without any BCAAs, and enough low-protein or protein-free foods to meet the patient’s daily caloric requirements. ![]() Most protein-rich foods, such as meat, dairy products, and eggs, however, contain high levels of BCAA s. Snyderman and his colleagues reported on the first successful dietary therapy for MSUD in 1964, which they accomplished by restricting the patients’ intake of foods containing high levels of branched-chain amino acids. The deficient enzyme, now known as branched-chain alpha-keto acid dehydrogenase complex, or BCKD, was purified and defined in 1978.įollowing Dancis’s work, S. (Illustration by GGS Information Services/Thomson Gale.)īreak down three branched-chain amino acids-leucine, isoleucine, and valine-during the process of digestion. In 1960, a researcher named Dancis established that the metabolic block in MSUD is caused by an insufficient supply of an enzyme that helps to An effective treatment, however, had to await further biochemical analysis of the metabolic dysfunction underlying the disease. The urine of these infants smelled like maple syrup or burned sugar, whence the disease got its name of maple syrup urine disease or MSUD. The family in Menkes’s case study had lost four infants within the first 3 months of life to a previously undescribed degenerative disorder of the nervous system. Menkes, a pediatrician, and his colleagues. Strict adherence to this diet is necessary to prevent developmental delays, mental retardation, and recurrent metabolic crises leading to respiratory failure and death. The special diet associated with MSUD is a low-protein diet characterized by restriction of a specific amino acid known as leu-cine the use of high-calorie liquid or gel formulas that are free of branched-chain amino acids ( BCAA s) and frequent monitoring of the BCAA levels in the patient’s blood plasma. Maple syrup urine disease ( MSUD ), which is also known as branched-chain ketoaciduria, branched-chain alpha-keto acid dehydrogenase deficiency, or BCKD deficiency, is a rare but potentially fatal inherited metabolic disorder ( IMD ) passed down in an autosomal recessive pattern.
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Altered carbon cast ms prescott12/2/2023 ![]() I hope everyone involved in making this production come to life continues to bring magic to Hollywood. I am not quite sure how Season 2 commanded a higher score than Season 1, they were both great, but Season 1 mastered the art of delivering a story and universe in an instant to the viewer. In life we see and experience things that sometimes just manage to harness the "right stuff" and makes your interaction with it a wildly satisfying interaction of emotions and thoughts. The ENTIRE cast delivered, in my opinion, awardable performances. This show takes you places and feel so much more than a production of sets and VFX. I wish I understood how shows like this don't gain the views the so deserve. Infill houses should consider the immediate neighbors: increased. Still an outstanding production and addition to the show none-the-less.Īrguable one of the greatest shows of all time and so little recognition. altered the site and the neighborhood character in an overkill kind of manner. I gave a 4.5 because I feel the second season didn't fully master the illusion of making the show feel as if it was all real as the first season did. Many fell in love with Kinnaman's larger than life delivery of Takeshi Kovacs, but if there was someone who could take on the complex mechanic of "resleeving" in a show and keeping the essence of the character, Mackie is the one. Set in a future where consciousness is digitized and stored, a prisoner returns to life in a new body and must solve a mind-bending murder to win his freedom. He was the one who found Takeshi Kovacs, seeing him as his son, trained him to be a CTAC Praetorian but eventually Kovacs betrayed Jaeger and joined the Uprising. With Chris Conner, Rene Elise Goldsberry, Dichen Lachman, Will Yun Lee. Many people were highly critical and dissatisfied of Mackie's performance.I disagree. Altered Carbon: Created by Laeta Kalogridis. Kinnaman brought Kovacs to life in a way you don't often see in movies and set the bar real high. That meant they both had to go on the run or risk being imprisoned.I provided my review to from Season 1 below but I did want to mention that Season 2 was fantastic as well. Upon seeing each other, Tak and Rei immediately turned on their partners - killing both the man with Rei and all the CTAC officers who were with Tak. Altered Carbon is set in the far future, at a time when a humans consciousness can be stored in a device called a Stack and transferred into different bodies, allowing people who have the means to become functionally immortal. During one raid assignment, Tak realizes that he's been sent to arrest (and/or kill) a man who is working with Rei. Tak agreed, and spent his formative years training as a CTAC soldier. Prescott is the Bancrofts lawyer, and often keeps in touch with the Bay City Police Department or other lower class companies on behalf of her wealthy clients. Then the two children were then found by CTAC - the Colonial Tactical Assault Corp (Protectorate military soldiers).Ī CTAC officer named Jaeger convinced Tak that he should join their force, and that Rei would be safer if he let her be adopted into another home. Their father murdered their mother and covered up the crime, and Tak killed their father in retaliation. elite soldier turned private investigator, to investigate a rich mans death. Set in a future in which interstellar travel and relative immortality is facilitated by transferring consciousnesses between bodies ('sleeves'), it follows the attempt of Takeshi Kovacs, a former U.N. Takeshi, or Tak, and Rei grew up in an abusive household. Altered Carbon is a 2002 cyberpunk novel by the English writer Richard K. The eight-episode Season 2 of the cyberpunk drama, which starred Anthony. For more, be sure to check out our spoiler-free review of Altered. EXCLUSIVE: Netflix has opted not to order a third season of the mind-bending, body-swapping sci-fi series Altered Carbon. ![]() Tak and Rei's time with the Envoys and the fallout Were rolling out a series of exclusive sneak peeks for Season 2 this week, so keep it locked right here for never-before-seen interviews and behind the scenes footage of Anthony Mackie as Takeshi Kovacs, Chris Conner as Poe, and Renée Elise Goldsberry as Quellcrist Falconer. It often indicates a user profile.īut in order to fully understand how Bancroft's "suicide" was connected to the mysterious Mary-Lou Henchy (and therefore tied to Ryker and Ortega), we'll have to start at the beginning. Account icon An icon in the shape of a person's head and shoulders.
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Icewind dale portraits bg112/2/2023 ![]() Certain mod items may not be affected by the item tweaks-in some cases, the tweak can't be made on the fly, so items to be modified are kept on static lists rather than a list made at installation time.The changes to Cromwell's dialogue in the Allow Cromwell to Upgrade Watcher's Keep Items component should play nicely with other mods, provided the other mods don't mangle his dialogue (ancient versions of Item Upgrade, for example).Multiple Strongholds (either variant) may not work correctly with Oversight's Cleric Kits component.The nothing kills romances option of Romance Cheats should be used with caution with third-party NPC romance mods.In addition, Tweaks Anthology is available on GitHub, so fixes and changes can be submitted by the community. If you should encounter any bugs, please report them to the authors at the Tweaks Anthology forum. ![]() For example, installing a mod that adds weapons after you install Alter Weapon Proficiency System from Tweaks will mean that the mod's weapons may not use the new system. As such, it is highly recommended that you install this mod last if you wish to take full advantage of it. Except where noted, the tweaks adjust items, dialogues, and other resources added by other mods. Every component in this mod makes interactive changes and should, in general, be compatible with other mods. While the mod works on all of these platforms, not every component is available for every game check the individual components for details using the acronyms listed above. The original Icewind Dale ( IWD) with or without either of its expansions, Heart of Winter ( HoW) and Trials of the Luremaster ( TotLM).The conversion projects Baldur's Gate Trilogy ( BGT), Baldur's Gate Tutu (Tutu), Icewind Dale-in-Baldur's Gate II ( IWD-in- BG2), and Enhanced Edition Trilogy ( EET).The original Baldur's Gate II ( BG2 or just Shadows of Amn ( SoA)), with or without the Throne of Bhaal ( ToB) expansion.The original Baldur's Gate ( BG), with or without the Tales of the Sword Coast ( TotSC) expansion.IWDEE includes Heart of Winter and Trials of the Luremaster. All of the Enhanced Edition games include the original expansion packs, e.g. The BGEE Siege of Dragonspear expansion ( SoD) is supported as well. The series of Enhanced Editions ( EE) published by Beamdog, which at present includes Baldur's Gate: Enhanced Edition ( BGEE), Baldur's Gate II: Enhanced Edition ( BG2EE), Icewind Dale: Enhanced Edition ( IWDEE), and Planescape: Torment: Enhanced Edition ( PsTEE).This mod works on all Infinity Engine games. This mod includes and deprecates a slew of other mods: the BG2 Tweak Pack, the G3 Tweak Pack, the Tutu Tweak Pack, Wes Weimer's Ease-of-Use, the Icewind Dale Tweak Pack, the Icewind Dale II Tweak Pack, the Baldur's Gate Tweak Pack, and the Planescape: Torment Tweak Pack.
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Key west vacation packages 202312/2/2023 ![]() ![]() Holiday Inn Club Vacations Incorporated, the Holiday Inn Club® program, and the Holiday Inn Club Vacations® resorts are independently owned, operated, and marketed and are not owned, operated or marketed by any InterContinental Hotels Group (“IHG”) companies, or by IHG One Rewards, or by the owner or licensor of the Holiday Inn® brand. Promotion not applicable with other discounted rate promotions. Shades of Green has been intentional and gradual in our approach to our COVID-19 health and safety protocols. Get the best rates and offers when your book direct with The Marker, including an array of Key West hotel deals and packages for your Florida Keys stay. Certain room types may be excluded from the promotion. Blackout dates may apply, and rooms are subject to availability. Taxes and resort fees may apply for each night of your stay. Centrally located on International Drive and near Orlandos best amusement parks and attractions, CoCo Key is the perfect hotel for your next family. Plus, you can even go island hopping for a more inclusive experience to see what each. You can enjoy tranquil accommodations just steps away from the shore with room for swimming, surfing, snorkeling, and more. ![]() Hawaii offers relaxing all-inclusive vacation experiences at beaches with tropical flair. Honolulu Hotels Key West Hotels Las Vegas Hotels Los Angeles Hotels. Enjoy an all-inclusive Hawaiian vacation. Full non-refundable deposit required at time of booking. Vacation Packages: Best Deals on Cheap Vacations & Travel Travelocity. A 2-night minimum stay is required, and stays must be booked at least 3 days prior to check-in date. The Book Early and Save promotion is valid only for rental stays booked through 7/29/23 for stays through 11/1/23. ** Destinations only available through IHG ® or external exchange companies. Oceans Edge Key West Resort, Hotel & Marina is located in Key West, and features an oceanfront location when youre ready to book your next trip. Fully refundable Reserve now, pay when you stay. To fulfill the terms of this offer, you are required to attend a two-hour timeshare sales presentation. Stunning beaches, relaxing spas, fine dining and more await travelers to these Florida Keys resorts. Oceans Edge Key West Resort, Hotel & Marina.
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Pleated spiral tie dye12/2/2023 Bull’s Eyeĭecide where on your shirt you want the center of your bull’s eye and pinch your shirt there, picking it up as you do. You can put a different color on each slice (do the front and the back), stick to a color “family” and pattern just 2 to 3 colors or even just use one color. ![]() Use each “slice” as guidance for where to put dye. With the rubber bands in place, your shirt will look like a sliced pizza. Secure with several rubber bands that overlap in the center. Keep twisting until your shirt is in a tight circle. You’ll notice that as you twist/rotate, your shirt will gather and the wrinkles will look like a spiral. Once you find it, pinch the center and then slowly twist your shirt. Remember: No rule says the center of your spiral must be in the center of your shirt. Spiral Dyeĭecide where you want the center of your spiral to be. If you’re not working from a kit, you’ll want to make sure you have rubber gloves, rubber bands (or string) and a plastic bag handy, as well. Other than that, the most important thing to keep in mind is something you probably already know: Dyeing is messy! Try to dye outside or plan on putting down a leak-proof drop cloth. Always wash your shirt (or any other material you’re dyeing) first and leave it slightly damp for the process. Prepping for tie dye is easier than you’d think. Here’s how to start: Prepping for Tie Dye With such a rich history behind it, this is a great way to have some fun and sneak in a history lesson to your little ones. RELATED: 26 Fun Indoor Games For Kids With Cabin Fever So You Can Catch A Break 500 to 800 but was also found in Japan, China, South Asia, and Africa. A reference to the process can be found in a 1941 book about the Philippines in which members of the Bagobo tribe are described as wearing “highly decorated clothing made of hemp fiber, all tied-and-dyed into fancy designs.” The practice of this ancient tradition even dates back to Peru as far back as A.D. Tie dyeing emerged and became a mainstay in pop culture in the 1960s, but the art is actually much older and meaningful. ![]() (Unpopular opinion: It’s also a great time to teach your kids how to use the washing machine on their own. Keep in mind, you can always use your coloring options as a chance to teach some science too. ![]() They’re going to keep those shirts or pillowcases around for as long as possible and always remember the giggle fits you had while tackling this fun project. And, honestly, the mess might be worth the fun, especially if you’re stuck in quarantine and social distancing during COVID-19. The tie dye process is proof that there is more than one way to earn a “green thumb” and let’s face it - your kiddos are “dyeing” to do it. But, just like when you tried to dye your hair purple at home, it can go wrong very quickly. Tie dyeing is so much fun and never seems to go out of style. Raise your hand if you’ve ever bought a tie dye kit with the best of intentions and then left it sitting in your laundry room for three years because you just didn’t have the emotional capacity to deal with the mess.
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Stellarium plus 1.7.6 apk12/2/2023 ![]() * Discover the 3D rendering of the main planets of the solar system and their satellites. ![]() * Simulate the landscape and atmosphere with realistic sunrise, sunset and refraction of the atmosphere. With this upgrade, the app will display objects as faint as magnitude 22 (versus magnitude 8 in the base version) and enable advanced observing features. Stellarium Plus features: View an accurate night sky simulation of stars and planets for any date, time and location. * Zoom in almost without limits on high resolution images of the Milky Way, deep sky objects or planetary surfaces. Stellarium Mobile contains in-app purchases allowing to upgrade to Stellarium Plus. * Reach the limits of knowledge by diving into a huge collection of stars, nebulae, galaxies, star clusters and other deep sky objects: Luchdaich sìos Stellarium Mobile PLUS Star Map 1.7.6 Mod an-asgaidh airson fònaichean-làimhe Android, fònaichean sgairteil. * View an accurate simulation of the night sky of stars and planets for any date, time and location. OA Shared Lust Doll Plus 18+ vr43.1 MOD APK: Age Restricted Games: 93: Sep 9, 2022: AOS APP Tested Omlet Arcade : Live Stream, Memes, NFT v1.90.11 MOD APK (Premium Plus Unlocked) Tested Android Apps: 19: Jul 27, 2022: FREE MOD Sift Heads Reborn Ver. Identify stars, constellations, planets, comets, satellites (such as the ISS) and other deep sky objects in real time in the sky above you in seconds, just by pointing the phone toward the sky! This award winning astronomy app has a simple to use and minimalist interface, making it one of the best astronomical apps for adults and kids who want to explore the night sky. Stellarium Mobile Plus – Star Map is a planetarium application that shows exactly what you see when you look at the stars.
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Black golden ticked tabby12/2/2023 This gives "silver" cats (which includes red cameo and smoke colors) the look of being lit from within, a bit of a glow. The silver gene causes the color in the hair to not be deposited at the base of the hair follicle! So if you pull the hair apart, the roots of the hair are. It's the removal of the yellow that makes the cat go from brown to silver, and the red go from brassy red to a softer red.Ģ. It turns a solid blue cat into a blue smoke. It turns a red tabby into a red silver, or "cameo" tabby. It turns a solid black cat into a black smoke. That means it turns a brown tabby into a silver tabby. The silver gene takes away the yellow from the coat color. Basically, the silver gene does two main things.ġ. The silver gene is dominant, so if only one parent has it, approximately half of the kittens will inherit it. If a brown cat gets the silver gene, they DO look silver, but if a red cat gets the silver gene, they don't look silver at all! So if you're confused, don't feel bad! I was too. ![]() This tabby is called a blotched tabby in some regions. Black (brown) Mackerel Mabby (with white) Red mackerel tabby - the archetypal 'ginger tom' or 'marmalade cat' Patched classic tabby on black-red tortie. So you cant have a non-agouti gene with an orange cat - meaning they will have some type of tabby marking, whether it is classic, mackerel, or ticked. However, when the red pigment gene is expressed, the non-agouti gene does not work. Here's the deal: whoever picked the term "silver" was getting a little ahead of themselves. Classic Tabby Cat The classic tabby has bold, swirling patterns along his sides much like a marble cake. The agouti gene determines whether a cat has a tabby pattern or not. ![]() *Confusing term alert! "Silver" does not always mean the coat looks silver.*
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Bubble bobble game12/2/2023 ![]() Other than that, the game plays mostly the same from the original. I feel like, the bad ending when you only play single player should have been added, because the whole original game was about teamwork. Although it is hard to add multiplayer to a mobile game, there are ways it can be added gracefully. Last would have to be the fact that the promotional things for this game tease multiplayer, something that isn’t actually shown in the game. And the bubble button should be bigger too. It’d be better to use a joystick like control on the left so that you can move and jump instead of pressing seperate buttons to do it. They’re to hard to use, and seems like they’re in the wrong places. They could have something like credits, since it is an arcade game. Second, I know this is a mobile game, but that doesn’t mean that we need gems to move on in the game. It looks like they just typed in some stuff and left it like that. I appreciate the classic game was brought to IOS, but the game has many problems. © TAITO CORPORATION 1986, 2020 ALL RIGHTS RESERVED. ![]() Clock: Freezing the monsters in certain amount of time. Magical necklaces: Shining ball bounces around the stage, and defeat the enemies. Chack’n Heart: Transforms to invincible Bubblun that defeat the enemies. Sky blue Ring: Able to get extra points each time the Bubblun moves. Magical staff: All remaining bubbles on the screen will turn into food, and also a large food will fall down. Depends on color of parasol, the jumped stages are different. Parasol: Allows to jump numerous stages. Holy water: Removing all enemies on the screen, and available to get additional scores in limited time. Lightning bubbles: Special bubble that can be blown horizontally to defeat the enemies. Fire bubbles: Special bubble that drops the fire and creates multiple fires. Water bubbles: Special bubble that flows the water down to defeat the enemies. Red shoes: Increasing Bubblun’s movement speeds. Blue candy: Increasing bubbles’ flying speed. Pink candy: Increasing range of blowing bubbles. Yellow candy: Increasing speed of blowing bubbles. Super game is available after normal game is cleared. Able to change the original or full screen aspect ratio in the setting. The skull monsters are going to appear and chase if the player cannot clear the stage in a certain amount of time. ![]() Able to get additional scores through hamburger, hot-dog, sushi, banana, and ice cream after defeating all enemies on the stage. Able to get an extra life through gathering alphabet bubbles E, X, T, E, N, D. Conveniently fire the bubbles with the automatic shot function. Comic Action Game with shooting bubbles to defeat enemies.Ĭlassic Arcade Game with the main character ‘Bubblun’ to capture enemies with bubble and defeat it.Īble to move left and right on the screen, and press the fire and jump buttons to play.
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Reviews of avast premium security12/1/2023 The antivirus software is compatible with Windows PCs, Macs, Android phones and tablets and iOS devices (iPhones). You can also use Avast on multiple devices with ease. It is intuitive, so you don’t need any in-depth training or instruction manuals – you can install it, update it and uninstall it all on your own. FeaturesĪvast antivirus is a feature-rich antivirus that offers a wide range of security features.įirst, Avast has a user-friendly interface that’s simple to navigate and easy to use. For this pricing, a custom quote is needed. The MSSPs and Resellers Advanced Protection Plan from AvastĪvast has a lot to offer whether you’re seeking comprehensive antivirus software for a reseller or a managed security service provider (MSSP).
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